{"id":5192,"date":"2025-10-08T10:56:04","date_gmt":"2025-10-08T05:26:04","guid":{"rendered":"https:\/\/windowsofnewthoughts.com\/?p=5192"},"modified":"2025-10-08T10:58:58","modified_gmt":"2025-10-08T05:28:58","slug":"brunkow-ramsdell-sakaguchi-nobel-prize","status":"publish","type":"post","link":"https:\/\/windowsofnewthoughts.com\/index.php\/2025\/10\/08\/brunkow-ramsdell-sakaguchi-nobel-prize\/","title":{"rendered":"Nobel Prize in Medicine 2025-\u092c\u094d\u0930\u0901\u0915\u094b, \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932, \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u0928\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928\u091a\u093e \u0928\u094b\u092c\u0947\u0932"},"content":{"rendered":"<p style=\"text-align: justify;\">\u0968\u0966\u0968\u096b \u0938\u093e\u0932\u0940 \u092e\u0947\u0930\u0940 \u0908. \u092c\u094d\u0930\u0901\u0915\u094b (Mary E. Brunkow), \u092b\u094d\u0930\u0947\u0921 \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 (Fred Ramsdell) \u0906\u0923\u093f \u0936\u093f\u092e\u094b\u0928 \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 (Shimon Sakaguchi) \u092f\u093e \u0924\u0940\u0928 \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u091c\u094d\u091e\u093e\u0902\u0928\u093e \u092b\u093f\u091c\u093f\u092f\u0949\u0932\u0949\u091c\u0940 \u0915\u093f\u0902\u0935\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928 (Physiology or Medicine) \u092f\u093e \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0924\u0940\u0932 \u0928\u094b\u092c\u0947\u0932 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930\u093e\u0928\u0947 \u0938\u0928\u094d\u092e\u093e\u0928\u093f\u0924 \u0915\u0930\u0923\u094d\u092f\u093e\u0924 \u0906\u0932\u0947.<br \/>\n\u0924\u094d\u092f\u093e\u0902\u0928\u093e \u0939\u093e \u0938\u0928\u094d\u092e\u093e\u0928 \u201cPeripheral Immune Tolerance\u201d \u092f\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0935\u0930\u0940\u0932 \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0938\u093e\u0920\u0940 \u092e\u093f\u0933\u093e\u0932\u093e.<\/p>\n<p style=\"text-align: justify;\">\u092f\u093e \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u092e\u0941\u0933\u0947 \u092e\u093e\u0928\u0935\u093e\u091a\u094d\u092f\u093e \u0936\u0930\u0940\u0930\u093e\u0924\u0940\u0932 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u0938\u094d\u0935\u0924\u0903\u0935\u0930 \u0939\u0932\u094d\u0932\u093e \u0915\u093e \u0915\u0930\u0924 \u0928\u093e\u0939\u0940 \u0906\u0923\u093f \u201cAutoimmune Diseases\u201d \u092e\u094d\u0939\u0923\u091c\u0947\u091a \u0936\u0930\u0940\u0930\u093e\u0928\u0947 \u0938\u094d\u0935\u0924\u0903\u091a\u094d\u092f\u093e \u092a\u0947\u0936\u0940\u0902\u0928\u093e \u0936\u0924\u094d\u0930\u0942 \u092e\u093e\u0928\u0942\u0928 \u0915\u093e \u0939\u0932\u094d\u0932\u093e \u0915\u0930\u093e\u0935\u093e \u0939\u0947 \u091f\u093e\u0933\u0932\u0947 \u091c\u093e\u0924\u0947, \u092f\u093e\u091a\u0947 \u0930\u0939\u0938\u094d\u092f \u0909\u0932\u0917\u0921\u0932\u0947.<\/p>\n<p style=\"text-align: justify;\"><strong>\u092e\u0941\u0916\u094d\u092f \u0938\u0902\u0936\u094b\u0927\u0928 (Core Discovery)<\/strong><\/p>\n<p style=\"text-align: justify;\">\u092f\u093e \u0924\u093f\u0928\u094d\u0939\u0940 \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u091c\u094d\u091e\u093e\u0902\u0928\u0940 Regulatory T Cells (Tregs) \u0928\u093e\u0935\u093e\u091a\u094d\u092f\u093e \u092a\u0947\u0936\u0940\u0902\u091a\u093e \u0906\u0923\u093f FOXP3 Gene \u091a\u093e \u0936\u094b\u0927 \u0932\u093e\u0935\u0932\u093e.<br \/>\n\u0939\u0947 \u0926\u094b\u0928\u094d\u0939\u0940 \u0918\u091f\u0915 \u0936\u0930\u0940\u0930\u093e\u091a\u094d\u092f\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0932\u093e \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u0920\u0947\u0935\u0924\u093e\u0924, \u092e\u094d\u0939\u0923\u091c\u0947\u091a \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u201c\u0938\u094d\u0935\u0924\u0903\u201d \u0906\u0923\u093f \u201c\u092a\u0930\u0915\u0940\u092f\u201d (Self vs Non-Self) \u092f\u093e\u0924\u0940\u0932 \u092b\u0930\u0915 \u0913\u0933\u0916\u0924\u0947.<\/p>\n<p style=\"text-align: justify;\">\u092f\u093e \u0938\u093f\u0926\u094d\u0927\u093e\u0902\u0924\u093e\u0932\u093e \u0935\u093f\u091c\u094d\u091e\u093e\u0928\u093e\u0924 Peripheral Immune Tolerance Mechanism \u092e\u094d\u0939\u0923\u0924\u093e\u0924.<br \/>\n\u0924\u094d\u092f\u093e\u092e\u0941\u0933\u0947 Autoimmune Disorders, Organ Transplant Rejection \u0906\u0923\u093f Cancer Immunotherapy \u092f\u093e \u0924\u093f\u0928\u094d\u0939\u0940 \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0902\u0924 \u092e\u094b\u0920\u0940 \u092a\u094d\u0930\u0917\u0924\u0940 \u0936\u0915\u094d\u092f \u091d\u093e\u0932\u0940.<\/p>\n<p style=\"text-align: justify;\"><strong>\u092e\u0947\u0930\u0940 \u0908. \u092c\u094d\u0930\u0901\u0915\u094b (Mary E. Brunkow)<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>\u0926\u0947\u0936 (Country): \u0905\u092e\u0947\u0930\u093f\u0915\u093e (United States of America)<\/strong><br \/>\n<strong>\u0938\u0902\u0936\u094b\u0927\u0928 \u0938\u0902\u0938\u094d\u0925\u093e (Research Institute): Institute for Systems Biology, Seattle<\/strong><\/p>\n<p style=\"text-align: justify;\">\u092c\u094d\u0930\u0901\u0915\u094b \u092f\u093e\u0902\u0928\u0940 \u0968\u0966\u0966\u0967 \u0938\u093e\u0932\u0940 Scurfy Mouse \u0928\u093e\u0935\u093e\u091a\u094d\u092f\u093e \u0909\u0902\u0926\u0930\u093e\u091a\u094d\u092f\u093e \u092a\u094d\u0930\u0915\u093e\u0930\u093e\u0924 FOXP3 Gene \u0936\u094b\u0927\u0932\u093e.<br \/>\n\u092f\u093e \u091c\u0940\u0928\u092e\u0927\u0940\u0932 \u0926\u094b\u0937\u093e\u092e\u0941\u0933\u0947 \u0924\u094d\u092f\u093e \u0909\u0902\u0926\u0930\u093e\u092e\u0927\u094d\u092f\u0947 \u0905\u0924\u093f\u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930 \u092a\u094d\u0930\u0924\u093f\u0915\u094d\u0930\u093f\u092f\u093e \u0926\u093f\u0938\u0942\u0928 \u0906\u0932\u0940.<br \/>\n\u0924\u094d\u092f\u093e\u0935\u0930\u0942\u0928 \u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0936\u094b\u0927\u0932\u0947 \u0915\u0940, \u092e\u093e\u0928\u0935\u093e\u092e\u0927\u094d\u092f\u0947\u0939\u0940 \u0939\u093e \u0926\u094b\u0937 \u0905\u0938\u0932\u094d\u092f\u093e\u0938 IPEX Syndrome \u0928\u093e\u0935\u093e\u091a\u093e \u0917\u0902\u092d\u0940\u0930 \u0906\u091c\u093e\u0930 \u0939\u094b\u0924\u094b.<\/p>\n<p style=\"text-align: justify;\">\u092f\u093e \u0936\u094b\u0927\u093e\u092e\u0941\u0933\u0947 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0924\u0940\u0932 Regulatory T Cells \u092f\u093e \u0928\u0935\u0940\u0928 \u092a\u0947\u0936\u0940\u0902\u091a\u093e \u092a\u094d\u0930\u0915\u093e\u0930 \u0938\u093f\u0926\u094d\u0927 \u091d\u093e\u0932\u093e.<br \/>\n\u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0926\u093e\u0916\u0935\u0942\u0928 \u0926\u093f\u0932\u0947 \u0915\u0940 FOXP3 Gene \u0939\u0947\u091a Tregs \u091a\u094d\u092f\u093e \u0935\u093f\u0915\u093e\u0938\u093e\u0938\u093e\u0920\u0940 \u0906\u0935\u0936\u094d\u092f\u0915 \u0905\u0938\u0924\u0947 (FOXP3 controls Treg development).<\/p>\n<p style=\"text-align: justify;\"><strong>\u092b\u094d\u0930\u0947\u0921 \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 (Fred Ramsdell)<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>\u0926\u0947\u0936 (Country): \u0905\u092e\u0947\u0930\u093f\u0915\u093e (United States of America)<\/strong><br \/>\n<strong>\u0938\u0902\u0936\u094b\u0927\u0928 \u0938\u0902\u0938\u094d\u0925\u093e (Research Institute): Parker Institute for Cancer Immunotherapy, San Francisco<\/strong><\/p>\n<p style=\"text-align: justify;\">\u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 \u0939\u0947 \u092c\u094d\u0930\u0901\u0915\u094b \u092f\u093e\u0902\u091a\u0947 \u0938\u0939\u0915\u093e\u0930\u0940 \u0905\u0938\u0942\u0928 \u0926\u094b\u0918\u093e\u0902\u0928\u0940 \u092e\u093f\u0933\u0942\u0928 FOXP3 \u091c\u0940\u0928\u091a\u093e \u0936\u094b\u0927 \u0932\u093e\u0935\u0932\u093e.\u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0926\u093e\u0916\u0935\u0942\u0928 \u0926\u093f\u0932\u0947 \u0915\u0940 \u0939\u093e \u091c\u0940\u0928 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0932\u093e \u201c\u092c\u094d\u0930\u0947\u0915\u201d \u0932\u093e\u0935\u0924\u094b \u2014 \u092e\u094d\u0939\u0923\u091c\u0947\u091a \u0936\u0930\u0940\u0930 \u0938\u094d\u0935\u0924\u0903\u0935\u0930 \u0939\u0932\u094d\u0932\u093e \u0915\u0930\u0924 \u0928\u093e\u0939\u0940.<br \/>\n\u0924\u094d\u092f\u093e\u0902\u091a\u094d\u092f\u093e \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u092e\u0941\u0933\u0947 Autoimmune Disorders \u0906\u0923\u093f Cancer Immunotherapy \u092f\u093e \u0926\u094b\u0928\u094d\u0939\u0940 \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0902\u0924 \u0928\u0935\u0947 \u0926\u093e\u0930 \u0909\u0918\u0921\u0932\u0947.<\/p>\n<p style=\"text-align: justify;\"><strong>\u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0924\u0940\u0932 \u092f\u094b\u0917\u0926\u093e\u0928 (Research Contribution):<\/strong><\/p>\n<p style=\"text-align: justify;\">FOXP3 Gene \u091a\u0940 \u0915\u093e\u0930\u094d\u092f\u092a\u094d\u0930\u0923\u093e\u0932\u0940 \u0938\u094d\u092a\u0937\u094d\u091f \u0915\u0947\u0932\u0940 (Explained Mechanism of FOXP3)<\/p>\n<p style=\"text-align: justify;\">Regulatory T Cells (Tregs) \u091a\u094d\u092f\u093e \u0905\u0938\u094d\u0924\u093f\u0924\u094d\u0935\u093e\u0932\u093e \u092a\u094d\u0930\u092f\u094b\u0917\u093e\u0902\u0928\u0940 \u0938\u093f\u0926\u094d\u0927 \u0915\u0947\u0932\u0947.<\/p>\n<p style=\"text-align: justify;\">\u201cImmune Brake\u201d \u0939\u0940 \u0928\u0935\u0940\u0928 \u0938\u0902\u0915\u0932\u094d\u092a\u0928\u093e \u0938\u093e\u0926\u0930 \u0915\u0947\u0932\u0940.<\/p>\n<p style=\"text-align: justify;\"><strong>\u0936\u093f\u092e\u094b\u0928 \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 (Shimon Sakaguchi)<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>\u0926\u0947\u0936 (Country): \u091c\u092a\u093e\u0928 (Japan)<\/strong><br \/>\n<strong>\u0938\u0902\u0936\u094b\u0927\u0928 \u0938\u0902\u0938\u094d\u0925\u093e (Research Institute): Osaka University, Japan<\/strong><\/p>\n<p style=\"text-align: justify;\">\u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u0928\u0940 \u0967\u096f\u096f\u096b \u092e\u0927\u094d\u092f\u0947\u091a \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0924 \u0915\u093e\u0939\u0940 \u0935\u093f\u0936\u0947\u0937 \u201c\u0928\u093f\u092f\u0902\u0924\u094d\u0930\u0915 \u092a\u0947\u0936\u0940\u201d \u0905\u0938\u0924\u093e\u0924 \u0905\u0938\u093e \u0938\u093f\u0926\u094d\u0927\u093e\u0902\u0924 \u092e\u093e\u0902\u0921\u0932\u093e \u0939\u094b\u0924\u093e.<br \/>\n\u092f\u093e \u092a\u0947\u0936\u0940\u0902\u0928\u093e \u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0928\u093e\u0935 \u0926\u093f\u0932\u0947 \u2014 Regulatory T Cells (Tregs).<br \/>\n\u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0926\u093e\u0916\u0935\u0932\u0947 \u0915\u0940 \u092f\u093e \u092a\u0947\u0936\u0940 IL-2 Receptor \u03b1-chain (CD25) \u0935\u094d\u092f\u0915\u094d\u0924 \u0915\u0930\u0924\u093e\u0924 \u0906\u0923\u093f \u0936\u0930\u0940\u0930\u093e\u0924\u0940\u0932 \u0938\u094d\u0935\u0924\u0903\u091a\u094d\u092f\u093e \u092a\u0947\u0936\u0940\u0902\u0928\u093e \u0928\u0937\u094d\u091f \u0939\u094b\u090a \u0926\u0947\u0924 \u0928\u093e\u0939\u0940\u0924.<\/p>\n<p style=\"text-align: justify;\">\u0928\u0902\u0924\u0930 \u092c\u094d\u0930\u0901\u0915\u094b \u0906\u0923\u093f \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 \u092f\u093e\u0902\u091a\u094d\u092f\u093e FOXP3 Gene \u091a\u094d\u092f\u093e \u0936\u094b\u0927\u093e\u0928\u0947 \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u091a\u094d\u092f\u093e \u0938\u093f\u0926\u094d\u0927\u093e\u0902\u0924\u093e\u0932\u093e \u092a\u0941\u0937\u094d\u091f\u0940 \u092e\u093f\u0933\u093e\u0932\u0940.<br \/>\n\u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0926\u093e\u0916\u0935\u0932\u0947 \u0915\u0940 \u201cFOXP3\u201d \u0939\u093e \u091c\u0940\u0928\u091a \u092f\u093e Regulatory T Cells \u091a\u094d\u092f\u093e \u0905\u0938\u094d\u0924\u093f\u0924\u094d\u0935\u093e\u0938\u093e\u0920\u0940 \u0906\u0935\u0936\u094d\u092f\u0915 \u0906\u0939\u0947.<\/p>\n<p style=\"text-align: justify;\"><strong>\u092a\u0930\u093f\u092b\u0947\u0930\u0932 \u0907\u092e\u094d\u092f\u0941\u0928 \u091f\u0949\u0932\u0930\u0928\u094d\u0938 \u092e\u094d\u0939\u0923\u091c\u0947 \u0915\u093e\u092f? (What is Peripheral Immune Tolerance?)<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>\u092a\u0930\u093f\u092d\u093e\u0937\u093e (Definition):<\/strong><br \/>\n\u0939\u0940 \u0905\u0936\u0940 \u0905\u0935\u0938\u094d\u0925\u093e \u0906\u0939\u0947 \u091c\u093f\u0925\u0947 \u0936\u0930\u0940\u0930\u093e\u091a\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u0938\u094d\u0935\u0924\u0903\u091a\u094d\u092f\u093e \u0928\u093f\u0930\u094b\u0917\u0940 \u092a\u0947\u0936\u0940\u0902\u0935\u0930 \u0939\u0932\u094d\u0932\u093e \u0915\u0930\u0940\u0924 \u0928\u093e\u0939\u0940.<br \/>\n\u0939\u0947 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u0923 Regulatory T Cells (Tregs) \u092f\u093e \u0935\u093f\u0936\u0947\u0937 \u092a\u0947\u0936\u0940\u0902\u092e\u093e\u0930\u094d\u092b\u0924 \u0918\u0921\u0924\u0947.<\/p>\n<p style=\"text-align: justify;\"><strong>\u092e\u0939\u0924\u094d\u0924\u094d\u0935 (Importance):<\/strong><\/p>\n<p style=\"text-align: justify;\">Autoimmune \u0906\u091c\u093e\u0930 (\u091c\u0938\u0947 Type 1 Diabetes, Rheumatoid Arthritis, Lupus) \u091f\u093e\u0933\u0923\u094d\u092f\u093e\u0938\u093e\u0920\u0940 \u0906\u0935\u0936\u094d\u092f\u0915 \u0905\u0902\u0917\u0926\u093e\u0928\u093e\u0928\u0902\u0924\u0930 (Organ Transplantation) \u0905\u0902\u0917 \u0928\u093e\u0915\u093e\u0930\u0923\u0947 \u0915\u092e\u0940 \u0939\u094b\u0924\u0947.<\/p>\n<p style=\"text-align: justify;\">Cancer Immunotherapy \u092e\u0927\u094d\u092f\u0947 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u092f\u094b\u0917\u094d\u092f \u0926\u093f\u0936\u0947\u0928\u0947 \u0928\u0947\u0923\u0947 \u0936\u0915\u094d\u092f \u0939\u094b\u0924\u0947.<\/p>\n<p style=\"text-align: justify;\"><strong>\u0935\u0948\u0926\u094d\u092f\u0915\u0940\u092f \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0924\u0940\u0932 \u0915\u094d\u0930\u093e\u0902\u0924\u093f\u0915\u093e\u0930\u0940 \u092a\u094d\u0930\u0917\u0924\u0940<\/strong><\/p>\n<p style=\"text-align: justify;\"><strong>\u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930 \u0935 \u092e\u093e\u0928\u094d\u092f\u0924\u093e (Awards and Recognition)<\/strong><\/p>\n<p style=\"text-align: justify;\">\u0928\u094b\u092c\u0947\u0932 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930 Karolinska Institute, Stockholm (Sweden) \u092f\u093e\u0902\u0928\u0940 \u091c\u093e\u0939\u0940\u0930 \u0915\u0947\u0932\u093e.<\/p>\n<p style=\"text-align: justify;\">\u090f\u0915\u0942\u0923 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930\u0930\u0915\u094d\u0915\u092e 11 Million Swedish Kronor \u0906\u0939\u0947.<\/p>\n<p style=\"text-align: justify;\">\u0939\u093e \u0938\u0928\u094d\u092e\u093e\u0928 \u092e\u093e\u0928\u0935\u093e\u091a\u094d\u092f\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u091a\u094d\u092f\u093e \u0938\u092e\u091c\u0941\u0924\u0940\u0924 \u092e\u0942\u0932\u092d\u0942\u0924 \u092c\u0926\u0932 \u0918\u0921\u0935\u0923\u093e\u0931\u094d\u092f\u093e \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0938\u093e\u0920\u0940 \u0926\u0947\u0923\u094d\u092f\u093e\u0924 \u0906\u0932\u093e.<\/p>\n<p style=\"text-align: justify;\"><strong>\u0924\u093e\u0924\u094d\u092a\u0930\u094d\u092f<\/strong><\/p>\n<p style=\"text-align: justify;\">\u092c\u094d\u0930\u0901\u0915\u094b, \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 \u0906\u0923\u093f \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u091a\u094d\u092f\u093e \u092f\u093e \u0938\u0902\u092f\u0941\u0915\u094d\u0924 \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u092e\u0941\u0933\u0947 \u0906\u0927\u0941\u0928\u093f\u0915 \u0935\u0948\u0926\u094d\u092f\u0915\u0936\u093e\u0938\u094d\u0924\u094d\u0930\u093e\u0924 \u090f\u0915 \u0928\u0935\u093e \u092f\u0941\u0917\u092a\u094d\u0930\u093e\u0930\u0902\u092d \u091d\u093e\u0932\u093e \u0906\u0939\u0947.<br \/>\n\u0924\u094d\u092f\u093e\u0902\u0928\u0940 \u0926\u093e\u0916\u0935\u0932\u0947 \u0915\u0940 \u0936\u0930\u0940\u0930\u093e\u091a\u0940 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u092b\u0915\u094d\u0924 \u0932\u0922\u0923\u093e\u0930\u0940 \u0928\u0938\u0942\u0928 \u0924\u0940 \u0935\u093f\u091a\u093e\u0930 \u0915\u0930\u0923\u093e\u0930\u0940 \u0935 \u0928\u093f\u092f\u0902\u0924\u094d\u0930\u093f\u0924 \u092a\u094d\u0930\u0923\u093e\u0932\u0940 \u0906\u0939\u0947.<\/p>\n<p style=\"text-align: justify;\">\u0924\u094d\u092f\u093e\u0902\u091a\u093e \u0936\u094b\u0927 Autoimmune Disease Treatment, Organ Transplant Success, \u0906\u0923\u093f Cancer Immunotherapy \u092f\u093e \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0924 \u0915\u094d\u0930\u093e\u0902\u0924\u0940 \u0918\u0921\u0935\u0923\u093e\u0930\u093e \u0920\u0930\u0932\u093e \u0906\u0939\u0947.<\/p>\n<p style=\"text-align: justify;\">\u0924\u094d\u092f\u093e\u092e\u0941\u0933\u0947 \u0968\u0966\u0968\u096b \u091a\u093e \u0928\u094b\u092c\u0947\u0932 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930 \u0915\u0947\u0935\u0933 \u0924\u0940\u0928 \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u091c\u094d\u091e\u093e\u0902\u091a\u093e \u0938\u0928\u094d\u092e\u093e\u0928 \u0928\u093e\u0939\u0940, \u0924\u0930 \u0924\u094b \u0938\u0902\u092a\u0942\u0930\u094d\u0923 \u092e\u093e\u0928\u0935\u091c\u093e\u0924\u0940\u091a\u094d\u092f\u093e \u0906\u0930\u094b\u0917\u094d\u092f\u0935\u093f\u0937\u092f\u0915 \u092a\u094d\u0930\u0917\u0924\u0940\u091a\u093e \u0909\u0924\u094d\u0938\u0935 \u0906\u0939\u0947.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0968\u0966\u0968\u096b \u0938\u093e\u0932\u0940 \u092e\u0947\u0930\u0940 \u0908. \u092c\u094d\u0930\u0901\u0915\u094b (Mary E. Brunkow), \u092b\u094d\u0930\u0947\u0921 \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 (Fred Ramsdell) \u0906\u0923\u093f \u0936\u093f\u092e\u094b\u0928 \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 (Shimon Sakaguchi) \u092f\u093e \u0924\u0940\u0928 \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u091c\u094d\u091e\u093e\u0902\u0928\u093e \u092b\u093f\u091c\u093f\u092f\u0949\u0932\u0949\u091c\u0940 \u0915\u093f\u0902\u0935\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928 (Physiology or Medicine) \u092f\u093e \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0924\u0940\u0932 \u0928\u094b\u092c\u0947\u0932 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930\u093e\u0928\u0947 \u0938\u0928\u094d\u092e\u093e\u0928\u093f\u0924 \u0915\u0930\u0923\u094d\u092f\u093e\u0924 \u0906\u0932\u0947. \u0924\u094d\u092f\u093e\u0902\u0928\u093e \u0939\u093e \u0938\u0928\u094d\u092e\u093e\u0928 \u201cPeripheral Immune Tolerance\u201d \u092f\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0935\u0930\u0940\u0932 \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0938\u093e\u0920\u0940 \u092e\u093f\u0933\u093e\u0932\u093e. \u092f\u093e \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u092e\u0941\u0933\u0947 \u092e\u093e\u0928\u0935\u093e\u091a\u094d\u092f\u093e \u0936\u0930\u0940\u0930\u093e\u0924\u0940\u0932 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u0938\u094d\u0935\u0924\u0903\u0935\u0930 \u0939\u0932\u094d\u0932\u093e \u0915\u093e \u0915\u0930\u0924 \u0928\u093e\u0939\u0940 \u0906\u0923\u093f &#8230; <a title=\"Nobel Prize in Medicine 2025-\u092c\u094d\u0930\u0901\u0915\u094b, \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932, \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u0928\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928\u091a\u093e \u0928\u094b\u092c\u0947\u0932\" class=\"read-more\" href=\"https:\/\/windowsofnewthoughts.com\/index.php\/2025\/10\/08\/brunkow-ramsdell-sakaguchi-nobel-prize\/\" aria-label=\"Read more about Nobel Prize in Medicine 2025-\u092c\u094d\u0930\u0901\u0915\u094b, \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932, \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u0928\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928\u091a\u093e \u0928\u094b\u092c\u0947\u0932\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":5195,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,281],"tags":[],"class_list":["post-5192","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-home","category-281"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u0968\u0966\u0968\u096b \u0938\u093e\u0932\u0940 \u092e\u0947\u0930\u0940 \u0908. \u092c\u094d\u0930\u0901\u0915\u094b (Mary E. Brunkow), \u092b\u094d\u0930\u0947\u0921 \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 (Fred Ramsdell) \u0906\u0923\u093f \u0936\u093f\u092e\u094b\u0928 \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 (Shimon Sakaguchi) \u092f\u093e \u0924\u0940\u0928 \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u091c\u094d\u091e\u093e\u0902\u0928\u093e \u092b\u093f\u091c\u093f\u092f\u0949\u0932\u0949\u091c\u0940 \u0915\u093f\u0902\u0935\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928 (Physiology or Medicine) \u092f\u093e \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0924\u0940\u0932 \u0928\u094b\u092c\u0947\u0932 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930\u093e\u0928\u0947 \u0938\u0928\u094d\u092e\u093e\u0928\u093f\u0924 \u0915\u0930\u0923\u094d\u092f\u093e\u0924 \u0906\u0932\u0947. \u0924\u094d\u092f\u093e\u0902\u0928\u093e \u0939\u093e \u0938\u0928\u094d\u092e\u093e\u0928 \u201cPeripheral Immune Tolerance\u201d \u092f\u093e \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940\u0935\u0930\u0940\u0932 \u092e\u0939\u0924\u094d\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u0938\u093e\u0920\u0940 \u092e\u093f\u0933\u093e\u0932\u093e. \u092f\u093e \u0938\u0902\u0936\u094b\u0927\u0928\u093e\u092e\u0941\u0933\u0947 \u092e\u093e\u0928\u0935\u093e\u091a\u094d\u092f\u093e \u0936\u0930\u0940\u0930\u093e\u0924\u0940\u0932 \u092a\u094d\u0930\u0924\u093f\u0915\u093e\u0930\u0936\u0915\u094d\u0924\u0940 \u0938\u094d\u0935\u0924\u0903\u0935\u0930 \u0939\u0932\u094d\u0932\u093e \u0915\u093e \u0915\u0930\u0924 \u0928\u093e\u0939\u0940 \u0906\u0923\u093f\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"sambhaji patil\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/windowsofnewthoughts.com\/index.php\/2025\/10\/08\/brunkow-ramsdell-sakaguchi-nobel-prize\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"en_GB\" \/>\n\t\t<meta property=\"og:site_name\" content=\"\u0928\u0935\u0947 \u0935\u093e\u0930\u0947 - \u0928\u0935\u0947 \u0935\u093f\u091a\u093e\u0930 - Travelogue,Gadkot Fort,Educational Thoughts,Competitive Exam Guidance,Real History of India and World,Philosophical Thoughts, Informative Blogs\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Nobel Prize in Medicine 2025-\u092c\u094d\u0930\u0901\u0915\u094b, \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932, \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 \u092f\u093e\u0902\u0928\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928\u091a\u093e \u0928\u094b\u092c\u0947\u0932 - \u0928\u0935\u0947 \u0935\u093e\u0930\u0947 - \u0928\u0935\u0947 \u0935\u093f\u091a\u093e\u0930\" \/>\n\t\t<meta property=\"og:description\" content=\"\u0968\u0966\u0968\u096b \u0938\u093e\u0932\u0940 \u092e\u0947\u0930\u0940 \u0908. \u092c\u094d\u0930\u0901\u0915\u094b (Mary E. 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Brunkow), \u092b\u094d\u0930\u0947\u0921 \u0930\u0945\u092e\u094d\u0938\u0921\u0947\u0932 (Fred Ramsdell) \u0906\u0923\u093f \u0936\u093f\u092e\u094b\u0928 \u0938\u093e\u0915\u093e\u0917\u0941\u091a\u0940 (Shimon Sakaguchi) \u092f\u093e \u0924\u0940\u0928 \u0936\u093e\u0938\u094d\u0924\u094d\u0930\u091c\u094d\u091e\u093e\u0902\u0928\u093e \u092b\u093f\u091c\u093f\u092f\u0949\u0932\u0949\u091c\u0940 \u0915\u093f\u0902\u0935\u093e \u092e\u0947\u0921\u093f\u0938\u093f\u0928 (Physiology or Medicine) \u092f\u093e \u0915\u094d\u0937\u0947\u0924\u094d\u0930\u093e\u0924\u0940\u0932 \u0928\u094b\u092c\u0947\u0932 \u092a\u0941\u0930\u0938\u094d\u0915\u093e\u0930\u093e\u0928\u0947 \u0938\u0928\u094d\u092e\u093e\u0928\u093f\u0924 \u0915\u0930\u0923\u094d\u092f\u093e\u0924 \u0906\u0932\u0947. \u0924\u094d\u092f\u093e\u0902\u0928\u093e \u0939\u093e \u0938\u0928\u094d\u092e\u093e\u0928 \u201cPeripheral Immune Tolerance\u201d \u092f\u093e 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